The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort
The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort
Abstract The COVID-19 pandemic has affected billions of people around the world not only through the infection itself but also through its wider impact on public health and daily life. To assess the effects of the pandemic, a team of researchers across a wide range of disciplines developed and implemented the Lifelines COVID-19 questionnaire, leading to the development of the Lifelines COVID-19 cohort. This cohort is recruited from participants of the Lifelines prospective population cohort and the Lifelines NEXT birth cohort, and participants were asked to fill out detailed questionnaires about their physical and mental health and experiences on a weekly basis starting in late March of 2020 and on a bi-weekly basis staring in June 2020. The Lifelines region covers the three Northern provinces of the Netherlands— Drenthe, Groningen and Friesland—which together account for ～10% of the Dutch population. To date, >70,000 people have responded to the questionnaires at least once, and the questionnaire program is still ongoing. Data collected by the questionnaires will be used to address four aspects of the outbreak: (1) how the COVID-19 pandemic developed in the three northern provinces of the Netherlands, (2) which environmental risk factors predict disease susceptibility and severity, (3) which genetic risk factors predict disease susceptibility and severity and (4) what are the psychological and societal impacts of the crisis. Informed consentAll Lifelines and Lifelines NEXT participants have provided informed consent that provide the opportunity for add-on research. Research involving human participantsBoth the Lifelines and the Lifelines NEXT studies were approved by the ethics committee of the University Medical Center Groningen.
van Blokland Irene、Boulogne Floranne、Dijkema Marjolein X.L.、Herkert Johanna C.、Lopera Maya Esteban A.、Reijneveld Sijmen A.、Vonk Judith M.、Swertz Morris、Sijtsma Anna、Scherjon Sicco A.、Franke Lude、Dekker Louise、Lanting Pauline、Intyre Kate Mc、Dekens Jackie、Deelen Patrick、Mierau Jochen O.、B¨1ltmann Ute、Wiersma Henry、Bakker Olivier、Brouwer Sandra、Claringbould Annique、Warmerdam Robert、Boezen H. Marike、van Ooijen R.、Jankipersadsing Soesma A.、Zhernakova Alexandra、Ori Anil P.S.、Angelini Viola、Zijlstra Elianne
University of Groningen, University Medical Center Groningen, Department of Genetics Groningen||Department of Cardiology, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenDepartment of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center GroningenDepartment of Epidemiology, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenLifelines Cohort StudyDepartment of Obstetrics and Gynaecology, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenFaculty of Economics and Business, University of Groningen||University Medical Center Groningen, Department of NephrologyUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics Groningen||Center of Development and Innovation, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics Groningen||Department of Genetics, University Medical Centre UtrechtFaculty of Economics and Business, University of Groningen||Aletta Jacobs School of Public HealthDepartment of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenDepartment of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenDepartment of Epidemiology, University of Groningen, University Medical Center GroningenDepartment of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics GroningenUniversity of Groningen, University Medical Center Groningen, Department of Genetics Groningen||Department of Psychiatry, University of Groningen, University Medical Center GroningenFaculty of Economics and Business, University of GroningenDepartment of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen
医学研究方法医药卫生理论预防医学
COVID-19population cohortpublic healthcomorbiditiespsychosocial impactgeneticsmedication
van Blokland Irene,Boulogne Floranne,Dijkema Marjolein X.L.,Herkert Johanna C.,Lopera Maya Esteban A.,Reijneveld Sijmen A.,Vonk Judith M.,Swertz Morris,Sijtsma Anna,Scherjon Sicco A.,Franke Lude,Dekker Louise,Lanting Pauline,Intyre Kate Mc,Dekens Jackie,Deelen Patrick,Mierau Jochen O.,B¨1ltmann Ute,Wiersma Henry,Bakker Olivier,Brouwer Sandra,Claringbould Annique,Warmerdam Robert,Boezen H. Marike,van Ooijen R.,Jankipersadsing Soesma A.,Zhernakova Alexandra,Ori Anil P.S.,Angelini Viola,Zijlstra Elianne.The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort[EB/OL].(2025-03-28)[2025-06-29].https://www.medrxiv.org/content/10.1101/2020.06.19.20135426.点此复制
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