丹参对糖尿病大鼠肾脏的保护作用及其机制
Salvia Miltiorrhiza Bunge Protected STZ-induced Diabetic Rats against Diabetic ephropathy
摘要]目的：探讨丹参治疗糖尿病肾病的作用及其机制。方法：采用单侧肾切除的STZ糖尿病大鼠，观测其肾脏形态、功能的变化。同时，采用荧光实时定量RT-PCR方法检测TGF-β1、CTGF、PAI-1等细胞因子在糖尿病大鼠肾脏中的表达情况。结果：与正常对照组（NC）相比，8周时糖尿病肾病组（DN）大鼠的肾脏肥大指数（KW/BW）、平均肾小球体积（VG）、尿白蛋白排泄率（UAER）、肌酐清除率（Ccr）均升高。DN组肾皮质CTGF、PAI-1、FN表达水平也有显著增高；丹参治疗组（DNS）的上述指标则均有明显下降。结论：丹参可通过抑制TGF-β1、CTGF、PAI-1等细胞因子的表达，对糖尿病大鼠肾脏起到保护作用。
alvia Miltiorrhiza Bunge Protected STZ-induced Diabetic Rats against Diabetic ephropathy LIU Gang, GUAN Guang-ju$, QI Tong-gang，FU Yu-qin, LI Xue-gang, SUN Yun, WU Tao, WEN Rong-zhu Department of Nephrology, the Second Hospital of Shandong University, Jinan 250033,China. [ABSTRACT] Objective:To explore the effects of Salvia miltiorrhiza Bunge on renal structure and function in diabetic rats. Methods:Male Wistar rats which underwent unilateral nephrectomy were randomly divided into 3 groups:normal control group (NC), streptozotocin-induced diabetic group(DN) and diabetic treated with Salvia miltiorrhiza Bunge (DNS).Urinary albumin excretion rate (UAER),creatinine clearance rate(Ccr), left kidney weight/body weight ratio(KW/BW) and glomerular volume (VG) were observed.The expression of transforming growth factor-beta1 (TGF-β1),connective tissue growth factor (CTGF), fibronectin(FN) and plasminogen activator inhibitor-1(PAI-1) were tested by real-time quantitative PCR at the end of
亓同钢、柳刚、李学刚、文蓉珠 、傅余芹 、吴涛 、关广聚、孙云
内科学基础医学中医学
糖尿病肾病丹参转化生长因子结缔组织生长因子纤溶酶原激活物抑制剂-1
diabetic nephropathySalvia miltiorrhiza Bungetransforming growth factor-beta1connective tissue growth factorplasminogen activator inhibitor-1
亓同钢,柳刚,李学刚,文蓉珠 ,傅余芹 ,吴涛 ,关广聚,孙云 .丹参对糖尿病大鼠肾脏的保护作用及其机制[EB/OL].(2005-08-08)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/200508-54.点此复制
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