肾移植受者小腿围与肌肉减少症的关系研究

Background The long-term prognosis of kidney transplant recipients (KTR) may be associated with sarcopenia, so early and rapid screening for sarcopenia in KTR is important, and the study suggests that calf circumference may be a good indicator for early screening for sarcopenia. Objective To analyze the relationship between calf circumference and sarcopenia in KTR,and to explore the feasibility of calf circumference in predicting KTR sarcopenia. Methods An 80 cases of KTR who were re-examined in the outpatient clinic of the Second People's Hospital of Guangdong Province from October 2021 to June 2022 were selected as the research subjects. Using the 2019 Consensus of Asian Working Group for Sarcopenia to diagnose sarcopenia, the multi-frequency human composition analyzer was used to measure body composition, and indicators such as grip strength, pinching force, waist circumference and calf circumference were measured, the difference in calf circumference between the sarcopenia group and the non-myosalgia group was compared stratified by sex, and the correlation between calf circumference and the diagnostic indicators of sarcopenia was compared, the association between calf circumference and the risk of sarcopenia was analyzed by multi-factor logistic regression, and the receiver operating characteristic (ROC) curve determined the optimal cut-off value for calf circumference prediction of sarcopenia. Results Calf circumference in the sarcopenia group was lower than that in the non-sarcopenia group in both genders (P=0.001P=0.004). Correlation analysis showed that the calf circumference was positively correlated with appendicular skeletal muscle mass (ASM), SMI and handgrip strength, difference was statistically significant. Univariate logistic regression analysis showed that the OR values for the risk of sarcopenia were 0.685, 95% CI: 0.526-0.892 for males, 0.432, 95% CI: 0.211-0.885 for females; after adjusting for other factors, there was no statistically significant association between calf circumference and sarcopenia risk in males and females. The ROC analysis indicated the cutoff value of the calf circumference was 33.3 cm (AUC = 0.799) for men predicting KTR sarcopenia and 32.2 cm (AUC = 0.851) for women. Conclusions KTR calf circumference is inversely correlated with sarcopenia, and the AUC of truncation value of calf circumference in KTR men and women was 0.799 and 0.851, respectively, suggesting that it has certain predictive value for KTR sarcopenia.