Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system
Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system
Abstract We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load in the post-stroke brain and reduced functional deficits without altering cerebral apoptosis, neuroinflammation or infarct volume. These findings indicate that the activation of the sympathetic nervous system after stroke promotes gut-derived bacteria to enter to the brain, and this process worsens motor function in mice. Abstract Figurebiorxiv;2023.04.03.535309v1/UFIG1F1ufig1
Jama Hamdi、Kemp-Harper Barbara K.、Modarresi Mahnaz、Wilson Jenny L.、Broughton Brad R.S.、Dinakis Evany、Rupasinghe Samoda、Wong Connie H.Y.、Barker Charlotte M.O.、Marques Francine Z.、Nakai Michael、Muralitharan Rikeish R.、Peh Alex、Zheng Tenghao
Hypertension Research Laboratory, School of Biological Sciences, Monash UniversityCardiovascular & Pulmonary Pharmacology Group, Department of Pharmacology, Monash UniversityCardiovascular & Pulmonary Pharmacology Group, Department of Pharmacology, Monash UniversityCentre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences at Monash Health, Monash Medical CentreCardiovascular & Pulmonary Pharmacology Group, Department of Pharmacology, Monash UniversityHypertension Research Laboratory, School of Biological Sciences, Monash UniversityCardiovascular & Pulmonary Pharmacology Group, Department of Pharmacology, Monash UniversityCentre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences at Monash Health, Monash Medical CentreCardiovascular & Pulmonary Pharmacology Group, Department of Pharmacology, Monash UniversityHypertension Research Laboratory, School of Biological Sciences, Monash University||Heart Failure Research Group, Baker Heart and Diabetes InstituteHypertension Research Laboratory, School of Biological Sciences, Monash UniversityHypertension Research Laboratory, School of Biological Sciences, Monash University||Institute for Medical Research, Ministry of Health MalaysiaHypertension Research Laboratory, School of Biological Sciences, Monash University||Cardiovascular & Pulmonary Pharmacology Group, Department of Pharmacology, Monash UniversityHypertension Research Laboratory, School of Biological Sciences, Monash University
基础医学神经病学、精神病学微生物学
strokegut microbiomedysbiosissympathetic nervous systeminfection
Jama Hamdi,Kemp-Harper Barbara K.,Modarresi Mahnaz,Wilson Jenny L.,Broughton Brad R.S.,Dinakis Evany,Rupasinghe Samoda,Wong Connie H.Y.,Barker Charlotte M.O.,Marques Francine Z.,Nakai Michael,Muralitharan Rikeish R.,Peh Alex,Zheng Tenghao.Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system[EB/OL].(2025-03-28)[2025-06-27].https://www.biorxiv.org/content/10.1101/2023.04.03.535309.点此复制
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