饮食与神经系统退行性疾病的关系的孟德尔随机化研究

In this paper explored the link between diet and neurodegenerative diseases: A Mendelian randomized study aimed to explore the relationship between diet and neurodegenerative diseases, and provide new ideas for the prevention of neurodegenerative diseases. We focused on common foods, including meat, cheese, vegetables, fruits, grains, and four types of alcohol, which were used as instrumental variables. In this study, the inverse variance-weighted (IVW) method, MR-Egger, weighted median method, weighted model and other analytical methods were used to verify the research results. IVW results showed that poultry [OR=9.503, 95%CI: 1.044-86.515, P=0.0457] was associated with Parkinson\'s disease, pork [OR=3.833, 95%CI: 1.277-11.502, P=0.0165], cheese [OR=1.472, 95%CI: 1.017-2.130, P=0.0400], beer [OR=3.148, 95% CI: 1.396-7.099, P=0.0057] was associated with Alzheimer\'s disease, fresh fruit [OR=692.900, 95%CI: 5.172-92822.239, P=0.0088] was associated with frontotemporal dementia, mutton [OR=0.343, 95%CI: 0.199-0.590, P=0.0001] was associated with amyotrophic lateral sclerosis, and salad [OR=7.655, 95% CI: 1.019-57.527, P=0.0479] was associated with dementia with Lewy bodies. In particular, the intake of poultry, pork, cheese, fresh fruit, salad, and beer was positively correlated with the risk of neurodegenerative diseases, and lamb was negatively correlated with the risk of amyotrophic lateral sclerosis. Others, including vegetables and grains, are not significantly associated with the occurrence of degenerative diseases of the nervous system.