Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)
Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)
Abstract The perceptual system gives priority to threat-relevant signals with survival value. Its mechanism may not only include the processing initiated in the presence of threat signals but also in the mere anticipation of such signals. Here, we show that the pulvinar modulates activity in the early visual cortex (V1) specifically in threat anticipation. Using ultra-high-field 7T fMRI, we examined the layer-specific interaction between V1 and the pulvinar, while taking advantage of the fact that the directionality of such interaction is anatomically constrained in specific V1 layers. Only in anticipation of a fearful face target, but not of a control happy face target, was false perception of anticipated-yet-unpresented target face accompanied by stronger activity in the V1 superficial-cortical-depth (layers 1-3), which was preceded by pre-target-onset pulvinar activity. The pulvinar may contribute to the visual processing initiated in the anticipation of threat, and play an important role in anxiety.
Zhan Minye、Koizumi Ai、Ban Hiroshi、Kida Ikuhiro、Martino Federico de、Amano Kaoru、Gelder Beatrice de
Department of Cognitive Neuroscience, Maastricht UniversityCenter for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT)||Graduate School of Frontier Biosciences, Osaka UniversityCenter for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT)||Graduate School of Frontier Biosciences, Osaka UniversityCenter for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT)||Graduate School of Frontier Biosciences, Osaka UniversityDepartment of Cognitive Neuroscience, Maastricht UniversityCenter for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT)||Graduate School of Frontier Biosciences, Osaka UniversityDepartment of Cognitive Neuroscience, Maastricht University
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
threat perceptionfearful face7 Tesla fMRIpulvinarV1cortical layer
Zhan Minye,Koizumi Ai,Ban Hiroshi,Kida Ikuhiro,Martino Federico de,Amano Kaoru,Gelder Beatrice de.Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)[EB/OL].(2025-03-28)[2025-05-21].https://www.biorxiv.org/content/10.1101/431270.点此复制
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