针刺、艾灸对快速老化小鼠海马神经干细胞增殖影响的差异性研究

o investigate the influence of acupuncture and moxibustion therapy on hippocmpual neurogenesis of senescence-accelerated mouse prone 8 (SAMP8). Methods Twenty-four SAMP8 mice were randomized equally into the model group,the acupuncture group and the moxibustion group, with 6 senescence-accelerated mouse/resistance SAMR1)as the control group. Acupuncture on Baihui（Du20）was administered once daily for 21 consecutive days in mice in the acupuncture group. After i.p BrdU into the body,the proliferation and differentiation of neural stem cell in hippocampus were dectected by immunohistochemistry, double-labled immunofluorescent. Results Both SAMP8 and SAMR1 group appearanced BrdU, BrdU/Nestin positive cells. Compared to SAMR1 group, the positive cells of SAMP8 group were obviously decreased（P﹤0.05）. Compared to the SAMP8 group, the positive cells of the acupuncture group were obviously increased（P﹤0.05）, and moxibustion group were also increased, but it was not statistically significant (P>0.05）. There were no significant difference between the acupuncture group and moxibustion group（P﹥0.05）.Conclusion After acupuncture and moxibustion treatment for 21 days, they can promote neural stem cells proliferation in the hippocampus, and the acupuncture group has a tendency to be better than that in the moxibustion group.