基于Van Leusen 反应合成新型吡咯衍生物反应的研究

he pyrrole ring compounds are important in medicine, pharmacy and in vivo. After many years of development, a variety of pyrrole ring derivatives have been successfully synthesized, but there are still some pyrrole ring small molecules that have not been prepared. In this paper, based on the mechanism of Van Leusen reaction, the novel pyrrole ring derivatives 1,1'-(1H-Pyrrole-3,4-diyl)diethanone were synthesized by one-step method using (E) -3-Hexene-2,5-dione and TOSMIC as the substrate under mild conditions. The synthesis of this new compound adds a new member to the pyrrole ring derivatives. In this paper, the synthesis of pyrrole derivatives by Van Leusen reaction was studied by using the carbon anion intermediates formed during the reaction as the starting point.