P-糖蛋白介导药物相互作用的研究方法

P-glycoprotein (P-gp) encoded by drug resistant gene and expressed in human normal tissues and in some tumor cells, is a very important factor to limit drug absorption, distribution, excretion, and maybe a factor for some tumor drug treatment failure; Researches on P-gp are very important significant to elucidate the drug-drug interactions (DDI) based on P-gp, can play a catalytic role in designing directed drug, reducing the drug development cycle. We often use different methods to predict drug intestinal absorption and distribution of tissues and organs, including in vivo, in situ and in vitro. In this paper, the current methods for P-gp research are reviewed.