MALAT1和miRNA

It is accepted that the noncoding RNA rather than coding one is more complex in higher eukaryotes. Small RNAs have been widely studied and long noncoding RNAs are becoming more instrested. Long noncoding RNAs regulate normal and tumor development. The length of human MALAT1 is about 8.7kb. MALAT1 has important biological action. MALAT1 regulates alternate splicing and then affects biological development. MicroRNAs(miRNAs) mainly locate in cytoplasm and control gene expression by targeting the mRNA of about 60% protein-coding genes, which are inhibited at post-transcription or RNAs of which are degraded. The reciprocal action of MALAT1 and miRNA is followed by: (1) MALAT1 and miRNA is completing to bind mRNA; (2)microRNA targets lncRNA to induce its degradation; (3) LncRNAs act as miRNA sponges. However, the relationship between MALAT1 and miRNA is unclear and needs to be further explored.