冬凌草甲素衍生物合成研究进展
dvances in the research of derivatives of oridonin
冬凌草甲素是从香茶菜属植物中提取得到的一种对应贝壳杉烯二萜类化合物，研究表明其在抑制肿瘤细胞增殖、诱导凋亡等方面有良好的活性。近些年来，国内外学者对冬凌草甲素进行结构修饰，得到了部分抗肿瘤活性更强、稳定性更好的冬凌草甲素衍生物。笔者对近些年来冬凌草甲素衍生物合成方法，及其抗肿瘤活性情况作一综述。
Oridonin is a corresponding ent-kaurene diterpenoid compound isolated from isodon genus, studies have shown that it has good activity in inhibiting tumor cell proliferation, apoptosis, etc. In recent years, domestic and foreign scholars has get several derivatives of oridonin with stronger anti-tumor activity, better stability. In this paper, the synthesis methods of oridonin derivatives and anti-tumor activity were reviewed.
刘宏民、可钰、付婷、王传金、拜金成、王繁华、王书波、李明明、李浩
药学肿瘤学基础医学
药物化学冬凌草甲素衍生物合成综述
pharmaceutical chemistryoridoninderivativessynthesissummarize
刘宏民,可钰,付婷,王传金,拜金成,王繁华,王书波,李明明,李浩.冬凌草甲素衍生物合成研究进展[EB/OL].(2013-12-11)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201312-231.点此复制
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