Studying the pathophysiology of coronavirus disease 2019 – a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)
Studying the pathophysiology of coronavirus disease 2019 – a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)
Abstract PurposeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, in order to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. MethodsPa-COVID-19 is a prospective observational cohort study of patients with confirmed SARS-CoV-2 infection treated at Charité - Universit?tsmedizin Berlin. We collect data on epidemiology, demography, medical history, symptoms, clinical course, pathogen testing and treatment. Systematic, serial blood sampling will allow deep molecular and immunological phenotyping, transcriptomic profiling, and comprehensive biobanking. Longitudinal data and sample collection during hospitalization will be supplemented by long-term follow-up. ResultsOutcome measures include the WHO clinical ordinal scale on day 15 and clinical, functional and health-related quality of life assessments at discharge and during follow-up. We developed a scalable dataset to (i) suit national standards of care (ii) facilitate comprehensive data collection in medical care facilities with varying resources and (iii) allow for rapid implementation of interventional trials based on the standardized study design and data collection. We propose this scalable protocol as blueprint for harmonized data collection and deep phenotyping in COVID-19 in Germany. ConclusionWe established a basic platform for harmonized, scalable data collection, pathophysiological analysis, and deep phenotyping of COVID-19, which enables rapid generation of evidence for improved medical care and identification of candidate therapeutic and preventive strategies. The electronic database accredited for interventional trials allows fast trial implementation for candidate therapeutic agents.
Spies Claudia、Ruwwe-Gl?senkamp Christoph、Thibeault Charlotte、Endres Matthias、Angermair Stefan、Weber-Carstens Steffen、Uhrig Alexander、Zoller Thomas、Suttorp Norbert、Sander Leif Erik、M¨1ller-Redetzky Holger、Hocke Andreas、Landmesser Ulf、Eckardt Kai-Uwe、Witzenrath Martin、R?hmel Jobst、Kurth Florian、Drosten Christian、Tacke Frank、Krannich Alexander、Schmidt Sein、Mockenhaupt Frank P.、Dang-Heine Chantip、Rose Matthias、Pieske Burkert、Roennefarth Maria、Mall Marcus A.、Corman Victor M.、Siegmund Britta、Treskatsch Sascha、Spranger Joachim、Knauss Samuel、Mittermaier Mirja、Kretzler Lucie、Hippenstiel Stefan、Kalle Christof von、H¨1bner Ralf H.、Hummel Michael
Department of Anesthesiology and Operative Intensive Care Medicine, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Neurology with Experimental Neurology and Center for Stroke Research Berlin, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Anaesthesiology and Intensive Care Medicine, Charite Campus Benjamin Franklin, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Anesthesiology and Operative Intensive Care Medicine, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Cardiology, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Nephrology and Internal Intensive Care Medicine, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of Health||Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-EppendorfInstitute of Virology, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Hepatology and Gastroenterology, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthClinical Study Center (CSC), Berlin Institute of Health, and Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu BerlinClinical Study Center (CSC), Berlin Institute of Health, and Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu BerlinInstitute of Tropical Medicine and International Health Berlin, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthClinical Study Center (CSC), Berlin Institute of Health, and Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu BerlinDepartment of Psychosomatic Medicine, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthMedical Department, Division of Cardiology, Campus Virchow-Klinikum, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthClinical Study Center (CSC), Berlin Institute of Health, and Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu BerlinDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthInstitute of Virology, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthMedical Department, Division of Gastroenterology, Infectious Diseases, Rheumatology, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Anaesthesiology and Intensive Care Medicine, Charite Campus Benjamin Franklin, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Endocrinology and Metabolism, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Neurology with Experimental Neurology and Center for Stroke Research Berlin, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthClinical Study Center (CSC), Berlin Institute of Health, and Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthClinical Study Center (CSC), Berlin Institute of Health, and Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charit¨| ¨C Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthCentral Biobank Charit¨| (ZeBanC), Institute of Pathology, Charit¨| Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of Health
医学研究方法基础医学临床医学
SARS-CoV-2COVID-19patient registryinfectious diseaseclinical phenotypingcoronavirus
Spies Claudia,Ruwwe-Gl?senkamp Christoph,Thibeault Charlotte,Endres Matthias,Angermair Stefan,Weber-Carstens Steffen,Uhrig Alexander,Zoller Thomas,Suttorp Norbert,Sander Leif Erik,M¨1ller-Redetzky Holger,Hocke Andreas,Landmesser Ulf,Eckardt Kai-Uwe,Witzenrath Martin,R?hmel Jobst,Kurth Florian,Drosten Christian,Tacke Frank,Krannich Alexander,Schmidt Sein,Mockenhaupt Frank P.,Dang-Heine Chantip,Rose Matthias,Pieske Burkert,Roennefarth Maria,Mall Marcus A.,Corman Victor M.,Siegmund Britta,Treskatsch Sascha,Spranger Joachim,Knauss Samuel,Mittermaier Mirja,Kretzler Lucie,Hippenstiel Stefan,Kalle Christof von,H¨1bner Ralf H.,Hummel Michael.Studying the pathophysiology of coronavirus disease 2019 – a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)[EB/OL].(2025-03-28)[2025-05-17].https://www.medrxiv.org/content/10.1101/2020.05.06.20092833.点此复制
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