Antiplasmodial Biodereplication Based on Highly Efficient Methods
Antiplasmodial Biodereplication Based on Highly Efficient Methods
We propose a biodereplication method using mass spectrometry and combining the classical dereplication approach with the predominant mechanism of action of antimalarial drugs. The method encompasses a biomimetic heme binding assay (heme adducts detection by MS), molecular networking for quick data mining, CPC for extract fractionation and compounds isolation and in silico modeling of heme adducts by molecular docking.
Alexandre Maciuk、Bruno Figad?§?§re、Sandrine Cojean、Carlos Amasifu?§|n、Elizabeth Mouray、Anne-C?§|cile Van Baelen、Karine Leblanc、Jean-Fran?ois Gallard、Guillaume Bernadat、Pedro V?§?ésquez-Ocm?§an、Philippe Grellier、Laurent Evanno
Alexandre MaciukBruno Figad?§?§reSandrine CojeanCarlos Amasifu?§|nElizabeth MourayAnne-C?§|cile Van BaelenKarine LeblancJean-Fran?ois GallardGuillaume BernadatPedro V?§?ésquez-Ocm?§anPhilippe GrellierLaurent Evanno
药学生物科学研究方法、生物科学研究技术生物化学
BiodereplicationPlasmodium falciparumhememass spectrometrybiomimetic
Alexandre Maciuk,Bruno Figad?§?§re,Sandrine Cojean,Carlos Amasifu?§|n,Elizabeth Mouray,Anne-C?§|cile Van Baelen,Karine Leblanc,Jean-Fran?ois Gallard,Guillaume Bernadat,Pedro V?§?ésquez-Ocm?§an,Philippe Grellier,Laurent Evanno.Antiplasmodial Biodereplication Based on Highly Efficient Methods[EB/OL].(2020-02-14)[2025-05-29].https://chemrxiv.org/engage/chemrxiv/article-details/60c7480bee301c96a0c797f0.点此复制
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