Ferroptosis induced by phenolic compound-iron complex
Ferroptosis induced by phenolic compound-iron complex
Abstract Phenolic compounds are the most ubiquitously distributed pollutants, and are highly toxic to living organisms, however the detailed mechanism how phenols exert toxic effects remains elusive. Here,Escherichia coli and phloroglucinol are adapted as proxy to elucidate the molecular mechanism of phenols’ toxicity. We demonstrated that phloroglucinol complexed with iron and promoted the generation of hydroxyl radicals in Fenton reaction, leading to reducing power depletion and lipid peroxidation, and further leading to ferroptosis-like cell death ofE. coli. This ferroptotic death can be triggered by various phenols in diverse organisms, from bacteria to mammalian cells. Furthermore, we demonstrated that phloroglucinol-induced ferroptosis suppressed tumor growth in mice effectively, indicating phloroglucinol as promising drug for therapy-resistant cancers. It’s also discovered that repression of this ferroptosis-like cell death benefited microbial degradation or production of desired phenolic compounds, showing great application potential in biotechnology field.
Xian Mo、Liu Bin、Liu Min、Shi Dayong、Li Shengying、Zhao Guang、Feng Xinjun、Fu Yingxin、Zhao Zhiqiang、Shi Cong、Sui Xinyue、Liu Miaomiao、Wang Jichao、Qi Qingsheng
CAS Key Lab of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of SciencesTEDA Institute of Biological Sciences and Biotechnology, Nankai UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University||CAS Key Lab of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of SciencesCAS Key Lab of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of SciencesState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityCAS Key Lab of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of SciencesState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityTEDA Institute of Biological Sciences and Biotechnology, Nankai UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong UniversityState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University
基础医学环境科学理论生物科学研究方法、生物科学研究技术
phenolic compoundstoxicityferroptosisFenton reactionhydroxyl radical
Xian Mo,Liu Bin,Liu Min,Shi Dayong,Li Shengying,Zhao Guang,Feng Xinjun,Fu Yingxin,Zhao Zhiqiang,Shi Cong,Sui Xinyue,Liu Miaomiao,Wang Jichao,Qi Qingsheng.Ferroptosis induced by phenolic compound-iron complex[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2023.05.23.541885.点此复制
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