Slit3对成纤维肉瘤HT1080细胞的侵袭转移的影响

xon guidance molecules,slits are secreted proteins that play an important role in axonal guidance, branching and neuronal migration. In recent years,slits are also found to involve the regulation of tumor growth,angiogenesis and metastasis. Fibrosarcoma,HT1080 cell ,which derived from mesenchymal tissues, is a highly metastatic malignant tumor.In this study,the expresion of slit3 and its effects on proliferation,migration and invasion of HT1080 are examined. The results showed that the silence of slit3 expression in HT1080 may be associated with promoter methylation.Addition of ectogenic slit3 suppressed the proliferation,migration and invasion of HT1080 significantly,which was further confirmed in vivo by intravenous injection experiment.