雌激素信号传导通路蛋白在子宫内膜癌中的表达及意义

Objective: To disuss the expression and significance of the key factors in estrogen signaling pathway in endometrial carcinoma. Methods:The expressions of Vav3、P-Akt protein in endometrial tissues were detected by using immunohistochemistry Elivison method. Results:The positive expression rate of Vav3 and P-Akt in normal endometrium, endometrial atypical hyperplasia and endometrial carcinoma had differences between them by statistic analysis (P<0.05). The positive expression rate of Vav3 in endometrial carcinoma was correlated with FIGO stages, differentiation degrees, myometrial invasion(P<0.05), The positive expression rate of P-Akt in endometrial carcinoma was correlated with FIGO stages, differentiation degrees, myometrial invasion,lymph nodes metastasis(P<0.05). There were positive correlations among the expression rates of Vav3, P-Akt, ER in endometrial carcinoma. Conclusion: Estrogen signaling pathway may play an important role in the incidence and development of endometrial carcinoma.