微重力效应对软骨细胞影响的研究进展

With the development of manned space technology and space biotechnology, biotechnology, the biological behaviors of cells and the involved molecular mechanisms in space have gradually become a hot topic and frontier of the space biology. Mechanical stimulation plays key roles in regulating the development and function of cells. Studies have demonstrated that mechanical stimulation participated in the proliferation, differentiation, migration and apoptosis of chondrocytes. In recent years，researchers have made significant achievements in biological behaviors of cells responding to microgravity environment by means of space simulation technology. This review mainly summarizes the changes in chondrocytes under microgravity and its related molecular mechanisms.