铅锌镉联合染毒及营养干预对大鼠生殖系统的影响研究

Purpose: In order to provide reference for the health protection measures of lead-zinc district occupational population and to understand the impact of rat reproductive system by combined exposure of lead zinc cadmium and nutrition intervention on repair of its damage. Methods: Selected early weaning rats 76 only, took 4 only as basal metabolism, the remaining rats were divided into three groups average: the control group, exposure group and intervention group. The control group was lavaged with physiological saline, the exposure group was lavaged with lead zinc cadmium mixture, the intervention group was lavaged with lead zinc cadmiumm mixture and nutrition intervention liquid. The rats were sacrificed after 28 days, Each group random selected 12 only rats. A total of rats were 36. We collected kidney and testis, calculated organ coefficient and inspected up its tissue by the microscope and then analyzed histopathological change. Results: The coefficient of rats kidney and testis in exposure group and control group comparison, difference has statistics meaning(P<0.05).The coefficient of rats kidney and testis in exposure group and intervention group comparison, difference has statistics meaning(P<0.05). Renal proximal convoluted tubules epithelial cells edema obvious and lumen has protein tube type in exposure group; Renal proximal convoluted tubules epithelial cells oedema, causing lumen is irregular and significant stenosis in intervention group. Testis spermatogenic epithelium damage, seminiferous tubule germ cells and sperm counts decrease. Seminiferous tubule germ cells and sperm counts decreased slightly in intervention group. Conclusion: It has obvious toxic effects for rat reproductive system by combined exposure of lead zinc cadmium, it can make its histopathological change; The comprehensive nutrition intervention has antagonism of a certain degree on combined exposure of lead zinc cadmium.