H2-K分子在小鼠中枢神经系统发育中表达模式的研究

Objective：To investigate the expression pattern of H2-K mRNA and the differences with H2-D. Methods The expression pattern of H2-K molecules in the developing central nervous system of mice by in situ hybridization. Results H2-K molecules are mainly expressed in the neuroepithelium of the lateral ventricle, cerebral cortex, aqueduct, the third ventricle, fourth ventricle, hippocampus primordium and cerebellar primordium in embryos by in situ hybridization; H2-K molecule is mainly expressed in the mitral cell layer of olfactory bulb, cerebral cortex, hippocampus, cerebellum and some nuclei in brainstem in postnatal stages. At the same time, the study found intensity of H2-D expression is higher than that of H2-K.