选择性芳香烃受体调节剂3，3-二吲哚甲烷抑制胃癌细胞生长
selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane ,inhibit gastric cancer cell growth
目的：探讨选择性芳香烃受体调节剂3，3-二吲哚甲烷（3,3'-Diindolylmethane，DIM）对胃癌细胞生长的影响。方法：用不同浓度(0, 10，20，30，40，50umol)的 DIM处理SGC7901细胞相应时间后，用MTT 法检测细胞的增殖，用流式细胞仪检测细胞周期和凋亡的变化。 结果：MTT 结果显示DIM 抑制胃癌细胞的生长，呈浓度和时间依赖性；流式细胞术结果显示，DIM阻滞细胞G1-S期进程，并促进细胞凋亡。结论：AhR 调节剂DIM通过促进细胞凋亡、阻滞细胞周期在G1 期来抑制细胞的增殖，AhR可能成为治疗胃癌的一个新靶点。
im: To explore the effects of selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane on gastric cancer cell growth.Methods: Gastric cancer cell SGC7901 was treated with DIM at different concentrations (0, 10, 20, 30, 40, 50umol); cell viability was measured by MTT assay, and the changes in cell cycle and apoptosis were analyzed by flow cytometry.Results: MTT assay indicated that the viability of SGC7901 cells was significantly decreased in a dose and time-dependent manner after DIM treatment. Flow cytometry analysis showed that DIM arrested cell cycle in G1 phase and induced cell apoptosis Conclusion: DIM can inhibit AGS cell proliferation by inducing apoptosis and delaying cell cycle progression. AhR may be a potential therapeutic target for gastric cancer treatment.
陈旻湖、陈洁、尹小菲
肿瘤学基础医学药学
胃癌hR细胞增殖细胞凋亡细胞周期
gastric cancerAhRcell proliferationcell apoptosiscell cycle
陈旻湖,陈洁,尹小菲.选择性芳香烃受体调节剂3，3-二吲哚甲烷抑制胃癌细胞生长[EB/OL].(2011-01-26)[2025-07-23].http://www.paper.edu.cn/releasepaper/content/201101-1265.点此复制
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