SSRP1基因多态性与肺癌化疗疗效的相关性研究
he association of SSRP1 genetic polymorphisms and lung cancer chemotherapy response
本文研究SSRP1基因多态性与中国汉族肺癌病人的铂类药物化疗敏感性的相关性。本研究共招募338名中国汉族肺癌病人，其中154名为铂类药物化疗敏感组，184名为铂类药物化疗耐药组。所有病人均接受了至少两个周期的铂类药物为基础的化疗作为一线治疗。共检测了该基因共6个SNPs。使用Sequenom Mass Array Genotype Platform进行基因型的检测。基因分型数据分析分别使用SPSS13.0对潜在的协变量进行筛选和使用Plink1.07软件中logistic回归分析基因多态性与铂类药物化疗敏感性的相关性。我们发现SSRP1基因多态性与铂类化疗反应不相关。此外，进一步多模型分析也未发现相关性。
In this paper, we investigated the association of SSRP1 genetic polymorphisms and platinum-based chemotherapy response in Chinese lung cancer patients. In total, 338 Chinese lung cancer patients (154 responders and 184 non-responders) were recruited. All patients received at least two cycle first-line platinum-based chemotherapy. Six tagging single nucleotide polymorphisms (SNPs) of SSRP1 were detected in patients. The Sequenom Mass Array Genotype Platform was used to detecting the genotype. The potential covariates on chemotherapy response were selected by using binary logistic regression with SPSS 13.0. The association between genotypes and chemotherapy response were tested by using logistic regression analysis with plink 1.07. We didn't find any association between SSRP1 genetic polymorphisms and platinum-based chemotherapy response. No significant associations were detected between these SNPs and platinum-based chemotherapy response in additive, recessive and genotypic models.
邹婷、钱晨月、王瑛、刘昭前、尹继业、陈娟
肿瘤学基础医学医学研究方法
肺癌SSRP1多态性铂类药物化疗
Lung cancer SSRP1 polymorphism platinum-based chemotherapy
邹婷,钱晨月,王瑛,刘昭前,尹继业,陈娟.SSRP1基因多态性与肺癌化疗疗效的相关性研究[EB/OL].(2014-12-09)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201412-211.点此复制
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