基于U-Net的病理图像细胞核分割
Pathological image segmentation of breast cancer cell nucleus based on U-Net
医学图像分割是图像处理的重要研究方向之一,而医学图像中对细胞核的分割是医生和病理学家对病症诊断、癌症级别分类评级的重要依据,但是如何高效精准分割病理图像中的细胞核一直是当下的研究热点。在细胞核的分割实验中,往往会因为细胞核的边缘轮廓信息模糊、细胞核与背景对比度低、各种器官的细胞黏连等问题造成分割效果差,甚至难以分割的情况。为解决上述问题,本文采用U-Net实现细胞核分割实验,U-Net采用下采样提取图像的浅层信息,通过上采样提取图像的深层信息,并通过跳跃连接结构使浅层信息和深层信息有效结合,从而可以实现精准的细胞核分割效果。本文通过U-Net在MoNuSeg公开数据集上进行测试,得到Dice系数为73.66%,mIoU达到73.78%,实验表明,U-Net网络是一种有效的细胞核分割方法。
Medical image segmentation is one of the important research directions of image processing, and the segmentation of cell nuclei in medical images is an important basis for doctors and pathologists to diagnose and classify cancer grades. However, how to efficiently and accurately segment cell nuclei in pathological images has always been the current research hotspot. In cell nucleus segmentation experiments, the segmentation effect is often poor or even difficult to segment due to the blurred edge contour information of the nucleus, the low contrast between the nucleus and the background, and the adhesion of cells in various organs. In order to solve the above problemsPathological image segmentation of breast cancer cell nucleus based on U-Net, this paper uses U-Net to realize the breast cancer cell segmentation experiment. U-Net uses downsampling to extract the shallow information of the image, extracts the deep information of the image through upsampling, and uses the skip connection structure to make the shallow information and the image. The deep information is effectively combined so that accurate nuclear segmentation can be achieved. In this paper, the U-Net is tested on the MoNuSeg public data set, the Dice coefficient is 73.66%, and the Miou intersection ratio reaches 73.78%. The experiments show that the U-Net network is an effective method for cell nucleus segmentation.
蒲秋梅、席作新
医学研究方法基础医学肿瘤学
深度学习U-Net网络医学图像细胞核分割
deep learningU-Net networkmedical imagecell nucleus segmentation
蒲秋梅,席作新.基于U-Net的病理图像细胞核分割[EB/OL].(2023-10-26)[2025-06-07].http://www.paper.edu.cn/releasepaper/content/202310-44.点此复制
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