黑曲霉浸没发酵中菌体形态的自动分析及控制

Filamentous fungi is widely applied in industrial fermentation. Moreover, the particular fungi morphology acts as a fatal index for a successful fermentation. Here, a systematical morphology analysis procedure was developed to obtain abundant morphological information efficiently. Meanwhile, this methodology was successfully applied to the study of Aspergillus niger morphology under different oxygen supply conditions and shear rate conditions. As a result, the responding pattern of Aspergillus niger morphology under these conditions was quantitatively demonstrated, which laid a solid foundation for the scale-up of fungal fermentation.