肠易激综合征内脏感觉过敏大鼠模型的血液流变学变化

Objective:To investigate changes of hemorheology on the model of visceral hypersensitivity of irritable bowel syndrome (IBS) in rats.Methods:Neonatal female SD rats received mechanical colonic stimulation between postnatal days 8 and 21.The abdominal withdrawal reflex (AWR) were recorded during colorectal distention when they became adults.At the end of the experiment，hemorheology parameters were examined.Result: Model rats treated with colorectal distention showed a significant increase in AWR compared with control rats ; The whole blood viscosity,the plasma viscosity,hematocrit,the whole blood reducing viscosity(in low shear rate）and the whole blood relative viscosity（in low shear rate）in model rats were obviously higher than those in control group (P<0.05 or P<0.01).Conclusion:There are some statistical changes of part hemorheological parameters in visceral hypersensitivity rats of IBS.