深部脑刺激有限元模型仿真研究
he deep brain stimulation study based on finite element simulation model
实验和临床研究表明,深部脑刺激可以抑制难治性脑部疾病和精神疾病,如帕金森、癫痫和抑郁症等。利用有限元仿真深部脑刺激,模拟电极电流在脑组织中的分布,提供了新的途径研究深部脑刺激机理。本文利用有限元仿真深部脑刺激模型,考虑电极-大脑接口,仿真和分析了单电极、双电极和多电极刺激模式下的组织内电流密度和电场分布,为进一步分析深部脑刺激对神经元、神经网络的影响打下基础。
linical and experimental studies reveal that, deep brain stimulation can inhibit the intractable brain diseases and mental disorders, such as Parkinson epilepsy and depression. It provides a new way to study the mechanism of deep brain stimulation that using the finite element simulate deep brain stimulation and electrode current distribution in the brain tissue. In this paper, the finite element is used to simulate deep brain stimulation model. Considering the electrode-brain interface, we simulateand analyse the current density and electric field distribution of organization under the stimulation mode of single electrode,dual-electrode and multi-electrode. The study lays the foundation for further analyse the impact of deep brain stimulation on neurons and neural network.
王丽莎、李小俚、崔冬
神经病学、精神病学医学研究方法基础医学
深部脑刺激有限元模型电极大脑接口电场分布
eep brain stimulationThe finite elementThe electrode-brain interfaceElectric field distribution
王丽莎,李小俚,崔冬.深部脑刺激有限元模型仿真研究[EB/OL].(2013-09-22)[2025-08-19].http://www.paper.edu.cn/releasepaper/content/201309-303.点此复制
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