呼出气监测丙泊酚血药浓度

Propofol accounts for about 70% market share of intravenous anesthetics in clinical surgery. With further research and application of total intravenous anesthesia, precision closed-loop anesthesia is proved to be important in clinical practice. It is necessary to monitor anesthetic dose, assess anesthesia effect, and evaluate anesthesia prognosis in a rapid and comprehensive way during the closed-loop anesthesia. Due to intravenous injection of anaesthetic, the difficulty to precisely monitor anaesthetic dose in blood has become the main limit for development of precision closed-loop anesthesia. In recent ten years, propofol detection using real-time breath monitoring developed rapidly with novel techniques and methods, which might break through the barrier of the closed-loop anesthesia. This study presents systems and methods using synchronized applications of gas chromatograph (GC) and surface acoustic wave (SAW) sensor for on-line monitoring propofol in exhaled gas. SPME-GC-MS was used to calibrate to GC-SAW sensor system for verifying feasibility, reliability, detection limit, and linearity. The propofol concentrations in exhaled gas was compared with concentrations in blood calculated by target-controlled infusion (TCI) . The results showed a high degree of consistency. In conclusion, GC-SAW system was proved to be a reliable way for clinical monitoring propofol concentration through patients' exhaled gas. This detection system would reduce the side effects of propofol intravenous anesthesia during surgery.