人参皂苷Rb1改善快速老化小鼠P8学习记忆功能障碍

We examined the effectd of long-term consumption of Rb1 on the cerebral Aβ content and cognitive performance in senescence-accelerated mouse prone 8 (SAMP8).Administration of ginsenoside Rb1 improved learning and memory outcomes in SAMP8 mice. Notably, a significant dose-dependent reduction of soluble Aβ1-40 wan shown in the hippocampus of SAMP8 mice after administration with ginsenoside Rg1 for 3 months. These data suggest that long-term consumption of gisenoside Rb1 may delay cognitive decline, associated with significant effects on Aβ generation in the hippocampus. These data provide further support for the therapeutic or intervention potency of gisenoside Rb1 ing the early stage of AD.