104例慢性呼吸道疾病并发下呼吸道感染的病原菌调查

Objective To explore the bacteria distribution and drug resistance of pathogens among lower respiratory tract infection (LRTI) inpatients with underlying chronic respiratory tract diseases, to assist empirical anti-infective therapy and avoid drug abuse, in order to avoid bacterial resistance. Methods The clinical data ,sputum culture and drug susceptibility results of 104 LRTI patients with various underlying chronic respiratory tract diseases who were hospitalized Respiratory ward of the First Hospital of Lanzhou University during September 2007 ~ August 2008 were analyzed.. Results 104 cases of patients with a total of 236 bacterial cultures, isolated 130 pathogens, including Gram-negative bacilli 83 (63.8%); gram-positive bacteria 9 (7%), fungi 38 (29.2% ). Infection in COPD patients with 49 pathogens of 53.1% was Gram-negative bacilli infections, Pseudomonas aeruginosa as the most important pathogens; patients with bronchiectasis exacerbated due to bacterial infection ,100% were caused by gram negative bacteria with Pseudomonas aeruginosa (58.3%),as the most frequent pathogens; Patients with pulmonary tuberculosis co-infection, Gram-negative bacilli accounted for 77.8 percent, Haemophilus influenzae are the most common pathogens, accounting for 33.3%. Conclusions Gram negative bacteria were the main pathogens of LRTI in hospitalized patients with underlying chronic respiratory tract diseases. The pathogens were influenced by basic disease、medication and Length of hospital stay, Correctly judge pathogens will help to determine the correct and effective anti-infective treatment.