真菌细胞自噬药靶发现与分子设计
iscovery and molecular design of inhibitors targeting autophagins in filamentous fungi
自噬现象是真核生物中广泛存在的过程，以酵母为模式生物发现的34种自噬相关基因在其他真核生物中一般都有同源基因。自噬在促进生存和诱导死亡中的双重作用仍存在较大争议。目前国内外关于自噬靶点的研究多集中在肿瘤细胞自噬现象，对于丝状真菌中自噬靶点尚没有相关研究报道。但可以预期的是，在自噬中扮演重要角色的蛋白，将很有可能成为治疗自噬网络中的关键蛋白，为接下来针对靶点的药物筛选提供研究基础。寻找自噬相关药靶为防治真菌病害提供了新的思路，但若要将自噬靶向药物真正运用于丝状真菌病害的防治还面临着严峻的挑战。
utophagy is an evolutionary conserved process in eukaryotic cells. 34 kind of authphagy-related genes(ATG) have been identified in model organism Saccharomyces crevisiae.The role of autophagy in promoting survival and induceing death remains largely controverisal. Domestic and overseas' research always focusing on targeting tumor cells,for the filamentous fungi， autophagy target is still not. But it can be expected that proteins play important role in autuphgay will probably be key protein in treatment autophagy network, which provides the basis for the inhibitors discovery. Althougy it is challenge to applieding autophgy targeted drugs to control plant filamentous fungi ,looking for autophagy related drug target provides new research tool
曹慧娟、林福呈
基础医学细胞生物学分子生物学
自噬药物靶标真菌病害
autophagydrug targetfilamentous fungi disease
曹慧娟,林福呈.真菌细胞自噬药靶发现与分子设计[EB/OL].(2012-02-29)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201202-1105.点此复制
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