Members of a highly widespread bacteriophage family are hallmarks of metabolic syndrome gut microbiomes
Members of a highly widespread bacteriophage family are hallmarks of metabolic syndrome gut microbiomes
Summary There is significant interest in altering the course of cardiometabolic disease development via the gut microbiome. Nevertheless, the highly abundant viral members-which impact gut bacteria-of the complex gut ecosystem remain understudied. Here, we characterized gut virome changes associated with metabolic syndrome (MetS), a highly prevalent clinical condition preceding cardiometabolic disease. MetS gut virome populations exhibited decreased richness and diversity, but larger inter-individual variation. These populations were enriched in phages infecting Bacteroidaceae and depleted in those infecting Ruminococcaeae. Differential abundance analysis identified eighteen viral clusters (VCs) as significantly associated with either MetS or healthy viromes. Among these are a MetS-associated Roseburia VC that is related to healthy control-associated Faecalibacterium and Oscillibacter VCs. Further analysis of these VCs revealed the Candidatus Heliusviridae, a highly widespread gut phage lineage found in 90+% of the participants. The temperate Ca. Heliusviridae are important novel research targets for understanding the role of the microbiome in human cardiometabolic health and developing microbiome-targeted interventions.
van den Born Bert-Jan H.、Zwinderman Aeilko H.、Nobrega Franklin L.、Nieuwdorp Max、Herrema Hilde、Scheithauer Torsten P.M.、Dutilh Bas E.、Wortelboer Koen、de Jonge Patrick A.
Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical CentersDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, Location AMC, University of AmsterdamSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of SouthamptonDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical CentersDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical CentersDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical CentersTheoretical Biology and Bioinformatics, Science for Life, Utrecht UniversityDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical CentersDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers
微生物学基础医学生物科学研究方法、生物科学研究技术
Metabolic SyndromeGut microbiomeGut viromeBacteriophageMetagenomics
van den Born Bert-Jan H.,Zwinderman Aeilko H.,Nobrega Franklin L.,Nieuwdorp Max,Herrema Hilde,Scheithauer Torsten P.M.,Dutilh Bas E.,Wortelboer Koen,de Jonge Patrick A..Members of a highly widespread bacteriophage family are hallmarks of metabolic syndrome gut microbiomes[EB/OL].(2025-03-28)[2025-05-21].https://www.biorxiv.org/content/10.1101/2021.03.30.437683.点此复制
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