YAP1蛋白调节AKT/mTOR信号通路在前列腺癌CRPC形成机制中的作用

Hormone independent progression is the underlying cause of death in patients with prostate cancer. However, until now, the mechanism of hormone independent prostate cancer (Castration resistant Prostate Cancer-CRPC) is unknown. The purpose of this study was to investigate the regulation of ADT signaling pathway in prostate cancer cells, and the regulation of AKT/mTOR signaling pathway in YAP1 may be a key factor in the development of CRPC. Through the screening of hormone independent prostate cancer specific cell signal transduction and regulation network, new diagnostic and therapeutic target screening for androgen independent prostate cancer, that can be used for the treatment of hormone independent prostate cancer molecular diagnosis, molecular typing and individualized targeted therapy. Objective: to propose a new therapeutic strategy for the treatment of advanced prostate cancer with androgen deprivation therapy (ADT) and the use of hormone independent prostate cancer targeted inhibitors.?????