喉鳞癌中Fascin-1和E-cadherin的表达及预后意义

Fascin-1 and E-cadherin which are related with cell motility and cell adhesiveness are important factors in the progression and metastasis of cancers. The objective of this study was to explore the association of Fascin-1 and E-cadherin expression level with clinical characteristics and prognosis of patients with laryngeal squamous cell carcinoma. In our study, tumor tissue samples from 150 patients with laryngeal squamous cell carcinoma were determined for Fascin-1 and E-cadherin expression by immunohistochemistry. The statistical analysis was performed to evaluate the association of Fascin-1 and E-cadherin expression with clinical characteristics and patient's prognosis. As a result, Fascin-1 expression was an independent predictive factors for recurrence in patients with laryngeal squamous cell carcinoma (P=0.021) and independently related to disease-free survival(P=0.010). Although E-cadherin expression status was not the independent predictive factors for recurrence (P=0.055) or disease-free survival (P=0.063), the subgroup with Fascin-1 high expression/E-cadherin low expression has the poorest prognosis (P=0.000) using subgroup analysis. In conclusion, Fascin-1 expression could be a potential prognostic predictor for patients with laryngeal squamous cell carcinoma. Simultaneous analysis of Fascin-1 and E-cadherin expression could be more effective to evaluate the prognosis of patients with laryngeal squamous cell carcinoma.