Dopamine biases sensitivity to personal goals and social influence in self-control over everyday desires
Dopamine biases sensitivity to personal goals and social influence in self-control over everyday desires
Abstract People regularly give in to daily temptations in spite of conflict with personal goals. To test hypotheses about neuropharmacological influences on self-control, we used positron emission tomography to measure dopamine D2-like receptors (D2R) and experience sampling surveys to naturalistically track daily desires outside the laboratory in everyday life in a sample of 103 adults. Higher D2R availability in the ventral striatum was associated with increased sensitivity to personal goal conflict but not desire strength in deciding whether to attempt to resist a desire. The influence of D2Rs on sensitivity to personal goal conflict depended on whether desires were experienced in a social context. D2R availability in the midbrain (but not the ventral striatum) influenced whether desires were enacted. These findings provide unique evidence that the dopamine system influences decision making and regulatory behavior and provides new insights into how these mechanisms interact with personal goals and social contexts.
Dang Linh C.、Zald David H.、Samanez-Larkin Gregory R.、Castrellon Jaime J.、Young Jacob S.、Cowan Ronald L.、Smith Christopher T.
Department of Psychology, Vanderbilt UniversityDepartment of Psychology, Vanderbilt University||Department of Psychiatry and Behavioral Sciences, Vanderbilt University||Department of Psychiatry, Rutgers Biomedical and Health SciencesDepartment of Psychology & Neuroscience, Duke University||Center for Cognitive Neuroscience, Duke UniversityDepartment of Psychology & Neuroscience, Duke University||Center for Cognitive Neuroscience, Duke UniversityDepartment of Neurosurgery, University of CaliforniaDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University||Department of Psychiatry, University of Tennessee Health SciencesDepartment of Psychology, Vanderbilt University
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
self-controlmotivationexperience sampling methodsdopaminepositron emission tomography
Dang Linh C.,Zald David H.,Samanez-Larkin Gregory R.,Castrellon Jaime J.,Young Jacob S.,Cowan Ronald L.,Smith Christopher T..Dopamine biases sensitivity to personal goals and social influence in self-control over everyday desires[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2021.09.10.459829.点此复制
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