N-多氟烷基-3-苯基-4-芳基亚甲胺基-1,2,4-三唑-5-硫酮的合成
Synthesis of N-Perfluoroaryl-4-(benzylideneamino)-3-phenyl
摘要
将3-苯基-4-芳基亚甲胺基-1,2,4-三唑与芳香醛在冰醋酸体系中反应，得到一系列杂环席夫碱3-苯基-4-芳基亚甲胺基-1,2,4-三唑-5-硫酮，为进一步改善其生物活性，本文在此基础上尝试引入多氟碘代烷合成了一系列的N-多氟烷基-3-苯基-4-芳基亚甲胺基-1,2,4-三唑-5-硫酮，并用1H-NMR, 19F-NMR, IR和MS表征了它们的结构。
Abstract
The reaction of 3-phenyl-4-(benzylideneamino)-1,2,4-triazole-5-thione with aromatic aldehydes gave a series of the Schiff bases 3-phenyl-4-(benzylideneamino)-1,2,4-triazole in glacial acetic acid medium. To improve their bioactivities, a series of N-perfluoroaryl-3-phenyl-4-(benzylidene amino)-1,2,4-tri- azole-5-thione were synthesized by introducing perfluorinated alkyl iodides in this paper and their structures were confirmed by 1H-NMR, 19F-NMR, IR and MS spectra.关键词
多氟烷基/1/2/4-三唑/4-芳基亚甲胺基-1/2/4-三唑-5-硫酮/合成Key words
perfluoroaryl/1/2/4-triazole/3-phenyl-4-(benzylideneamino)-1/2/4-triazole-5-thione引用本文复制引用
尹凯,黄勇,周后相,向建南,蒋历辉.N-多氟烷基-3-苯基-4-芳基亚甲胺基-1,2,4-三唑-5-硫酮的合成[EB/OL].(2007-01-26)[2026-04-03].http://www.paper.edu.cn/releasepaper/content/200701-382.学科分类
有机化学工业/制药化学工业/精细化学工业
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