Designing the ASPIRE-SSI study: a multicenter, observational, prospective cohort study to assess the incidence and risk factors of surgical site and bloodstream infections caused by Staphylococcus aureus in Europe
Designing the ASPIRE-SSI study: a multicenter, observational, prospective cohort study to assess the incidence and risk factors of surgical site and bloodstream infections caused by Staphylococcus aureus in Europe
ABSTRACT BackgroundThere is a continuing need for in-depth and updated knowledge about the epidemiology of surgical site infections (SSIs) caused by Staphylococcus aureus to support the development of effective preventive interventions. The ASPIRE-SSI study aims primarily to determine the incidence of S. aureus SSIs and postoperative bloodstream infections (BSIs) in Europe and to assess their association with patient-related, pathogen-related, and contextual risk factors. MethodsASPIRE-SSI is a prospective, multicenter, observational cohort study primarily assessing the incidence of and risk factors for S. aureus SSI and postoperative BSI in Europe. Five thousand adult surgical patients (of which two-thirds will be S. aureus carriers and one-third non-carriers) undergoing several types of surgical procedures in sites located across Europe were enrolled in the study. Data and specimens were collected from these subjects who were followed for up to 90 days following surgery to assess study outcomes.Using advanced survival analyses and regression techniques (including competing risks models), we will determine event-specific and sub-distribution hazards to assess the independent associations of these study outcomes with risk factors. Additionally, a risk prediction model will be derived to quantify the risk of developing SSI or BSI due to S. aureus. DiscussionDespite the challenges, this study will provide important and contemporary information about the epidemiology of SSI and BSI (and other infections) caused by S. aureus in the current surgical population in Europe, thereby supporting the development of effective preventive interventions. Trial registrationclinicaltrial.gov number NCT02935244
Harbarth Stephan、Ali Omar、Weber Susanne、Hazard Derek、Vilken Tuba、Sifakis Frangiscos、Timbermount Leen、Wolkewitz Martin、Troeman Darren P.R.、Kluytmans Jan A.J.W.
Infection Control Programme and WHO Collaborating Center, Geneva University Hospitals and Faculty of MedicineMicrobial Sciences, BioPharmaceuticals R&DInstitute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg||Freiburg Center for Data Analysis and Modeling, University of FreiburgInstitute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg||Freiburg Center for Data Analysis and Modeling, University of FreiburgLaboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of AntwerpBoehringer Ingelheim PharmaceuticalsLaboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of AntwerpInstitute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg||Freiburg Center for Data Analysis and Modeling, University of FreiburgJulius Center for Health Sciences and Primary care, University Medical Center Utrecht||Utrecht UniversityJulius Center for Health Sciences and Primary care, University Medical Center Utrecht||Utrecht University||Amphia Hospital
医学研究方法预防医学外科学
Staphylococcus aureusSurgical site infectionPostoperative infectionBloodstream infectionBacteremiaStaphylococcus aureus carriageEpidemiological studyEurope
Harbarth Stephan,Ali Omar,Weber Susanne,Hazard Derek,Vilken Tuba,Sifakis Frangiscos,Timbermount Leen,Wolkewitz Martin,Troeman Darren P.R.,Kluytmans Jan A.J.W..Designing the ASPIRE-SSI study: a multicenter, observational, prospective cohort study to assess the incidence and risk factors of surgical site and bloodstream infections caused by Staphylococcus aureus in Europe[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2020.07.08.20148791.点此复制
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