柳珊瑚内生真菌Aspergillus versicolor的天然产物研究

Objective: to uncover the typical structures and the structural diversity derived from a gorgonian endophytic fungus; Method: rice solid fermentation was used for the fungus culture in laboratory scale, comprehensive column chromatography was applied for the isolation and purification of compounds, extensive spectroscopic data were used for the structure determination; Results: 23 natural products were isolated, and their structures were determined, including a new compound (1), while the absolute configurations of compound (2) which were uncertain in the literature were assigned in present work, compounds 1-3 exhibited inhibitory effects against a panel of tumor cell lines;Conclusion: Chemical examination of the marine-derived fungus A. versicolor resulted in the isolation of 23 natural products, including a new compounds. The absolute configurations and the NMR data of compound (2) which were uncertain in the literature were assigned in the present for the first time. The inhibitory effects compounds 1-3 against a panel of tumor cell lines suggested 1-3 to be the model molecules for further structural modification. The present work indicated that the same strain of fungus encoded diverse biogenetic pathway, while a fungal strain from different location activated synthetic pathway to produce distinct secondary metabolites.