聚丙烯酸人工晶状体表面聚电解质多层膜的构建及表面特性评价

bstract: Objective: Surface modification with layer-by-layer self-assembly technique was carried out to improve the biocompatibility of hydrophobic acrylate intraocular lens (IOL). Methods: The polyelectrolyte multilayered films (PEMs) were constructed by the alternate deposition of poly(L-lysine) (PLL) andhyaluronic acid (HA) onto the surface of the acrylate IOLs. Changes of the surface-modified IOL surface in hydrophilicity was comprehensively evaluated by water contact angle (WCA) measurements. The surface biocompatibility of IOLs was compared with the adhesion behavior of macrophages in vitro. Results: After PEMs construction, the hydrophilicity of the IOL surface was obviously improved. The PEMs modified IOLs resisted the adhesion of macrophages significantly. Conclusions: PEMs was successfully constructed on the IOL surface with layer-by-layer self-assembly technique. Improved hydrophilicity and inhibition of cell adhesion were confirmed. Slighter foreign-body reaction may be expected after implantation of PEMs-modified IOL.