99mTc标记制备的主动靶向整合素αvβ3受体发展与肿瘤诊断关系的meta分析

OBJECTIVE: To investigate the relationship between the activity of the active targeting integrity αvβ3 receptor prepared by 99mTc labeling and the diagnosis and staging of tumors. Methods: In order to get the literature suitable for meta-analysis, the Chinese knowledge network CNKI, Wanfang data knowledge service platform, Weipu journal resource integration service platform and Pubmed database were searched. The inclusion criteria are built on the diagnostic criteria recommended by the Cochrane Collaboration. Spearman correlation coefficients were computed using Meta-Sc1.4 software, combined effect values and heterogeneity were tested for sensitivity logarithm, (1-specific) logarithm using a fixed effect model or a random effects model. Results: After searching China Knowledge Network, Wanfang Database and Weipu Database, there were 72 articles. After looking at the literature carefully, nine articles met the research criteria. Meta-analysis combined sensitivity and specificity were 0.84, 0.70 (95% CI = 0.80-0.87, 0.62-0.78), respectively, confirming that the development of 99mTc-labeled active targeting integrity αvβ3 receptor can promote tumor diagnosis. Conclusion: The development of 99mTc-labeled active targeting integrity αvβ3 receptor can promote the diagnosis of tumors.