室旁核在脑缺血致大鼠心律失常中的作用
Effect of the paraventricular nucleus of the hypothalamus in arrhythmias induced by cerebral ischemia
目的：研究室旁核在脑缺血所致的心律失常中的作用，探讨脑心综合征的发病机制。方法：用线栓法栓塞右侧大脑中动脉建立脑心综合征模型，监测心电，免疫组化和Western blotting方法测定大鼠室旁核内c-fos表达的变化。结果：模型组大鼠心律失常的发生率为71%显著高于假手术组（p<0.01），发生时间约为栓塞后(13±9.89)min，可持续时间约为(28.5±12.89)min。免疫组织化学和Western blotting结果显示，脑缺血后15min和30min时大鼠室旁核内c-fos的表达明显升高（P<0.05）。结论：大鼠局灶性脑缺血发生的心律失常与室旁核活动增强有关。
Objective To investigate the effect of the paraventricular nucleus of the hypothalamus in arrhythmias induced by Cerebral Ischemia. Methods The cerebro-cardiac syndrome model rats were induced by occluding fight middle cerebral artery and the ECG was monitored．C-fos levels of paraventricular after cerebral ischemia were determined using immunohistochemistry and western blot. Results The rate of arrhythmia in MCAO rats was 71%, which was obviously higher than sham group(P<0.01). According to the results of immunohistochemistry and Western blotting，compared with the control group, the level of c-fos expression was remarkably increased in 15min,30min and 4h after MCAO (P<0.05). Conclusion The activity of PVN is close correlated with the arrhythmias induced by cerebral ischemia.
贾淑伟、王娜、夏青、赵剑、王玲
基础医学神经病学、精神病学内科学
脑缺血室旁核心律失常c-fos
cerebral Ischemiaparaventricularcardiac arrhythmiac-fos
贾淑伟,王娜,夏青,赵剑,王玲.室旁核在脑缺血致大鼠心律失常中的作用[EB/OL].(2012-03-30)[2025-05-25].http://www.paper.edu.cn/releasepaper/content/201203-821.点此复制
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