莫匹罗星的临床研究进展

ue to the wide spread use and abuse of antibiotics, the bacterial infection caused by methicillin-resistant Staphylococcus aureus (MRSA) has become increasingly serious. It has developed resistance to vancomycin, which is commonly used in clinical practice. The progress of new antibiotic research and development is far behind the development rate of drug-resistant bacteria. Facing such super bacteria, human health and safety are greatly threatened. Mupirocin has good antibacterial activity against most Staphylococcus aureus, especially methicillin-resistant Staphylococcus aureus. The unique antibacterial mechanism of mupirocin provides a new option for the treatment of bacterial infection. Due to its rapid metabolism in vivo, it is only used for topical administration. And its drug resistance has been reported. To explore the potential for clinical applications of mupirocin, the research progress on the physicochemical properties and clinical applications of mupirocin are discussed here.