2型糖尿病患者尿微量白蛋白排泄率与C5a的关系
study of the relationship between complement
目的 探讨2型糖尿病患者血、尿补体活化片段C5a含量的变化与糖尿病肾病的关系。方法 选2型糖尿病患者39例，健康体检自愿者21人作为对照，检测血、尿C5a浓度以及血高敏C反应蛋白，测定尿微量白蛋白排泄率以及血糖控制情况，分析其关系。结果 与对照组比较，2型糖尿病患者尿C5a浓度升高（11.4±21.2比76.4±144.5，P =0.046），血C5a无明显变化，尿C5a与尿微量白蛋白排泄率正相关（r =0.378，P =0.023），糖尿病病程、尿C5a是尿微量白蛋白排泄率的独立预测因素。结论 补体活化可能与糖尿病肾病的发生有关。
Objective To investigate the relationship between complement C5a and diabetic nephropathy. Methods The concertration of plasma C5a and urine C5a was examined in 39 patients with type 2 diabetes mellitus, 21 healthy volunteers served as controls . The relationship between complement C5a and UAER was analyzed. Resuts Compared with healthy controls, urine level of C5a was increased significantly in the diabetic nephropathy group（11.4±21.1 vs 76.3±144.4，P=0.046）, which was positively correlated with UAER. The diabetic course and urine C5a are the independent predictors of urine albumin excretion rate（r =0.378，P =0.023. Conclusion The activation of complements might involve in the pathogenesis of chronic diabetic renal complication.
杨琳、刘永铭、周新人
内科学基础医学临床医学
2型糖尿病尿微量白蛋白排泄率尿C5a、血C5a
ype 2 diabetesurine albumin excretion rateplasma C5a and urine C5a
杨琳,刘永铭,周新人.2型糖尿病患者尿微量白蛋白排泄率与C5a的关系[EB/OL].(2009-04-08)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/200904-237.点此复制
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