The Risk of Secondary Malignancies in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis
The Risk of Secondary Malignancies in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis
Abstract This study was performed to systematically asses the risk of secondary malignancies in patients with ovarian cancer. We conducted a systematic search in PubMed, Web of Science, and Scopus databases up to September 2019 to find target studies. In this study, the overall SIR has been calculated with fixed/random-effects models. Sixteen cohort studies including 122715 ovarian cancer patients with 4458 secondary malignancies have been included in this meta-analysis. Combined SIRs showed an increased risk of secondary malignancies prevalence (SIR: 1.81, 95%CI 1.58-2.03). The most prevalence diagnosed malignancies were as follows: breast cancer (1.34, 95%CI 1.5-1.18), intestine (2.36, 95%CI 1.11-3.61), colorectal (1.73, 95%CI 1.44-2.02), pancreatic (1.42, 95%CI 1.13-1.71), cervical cancer (11.57, 95%CI 6.94-16.21), renal (1.43, 95%CI 1.11-1.74), bladder (2.13, 95%CI 1.77-2.50), leukemia (3.33, 95%CI 2.23-4.43), connective tissue (2.61, 95%CI 1.56-3.66), and thyroid (1.59, 95%CI 1.13-2.04). In regards to the results, various malignancies have a greater prevalence in patients with ovarian cancer in comparison to the general public. Corpus cancer, leukemia cancer, endometrium cancer, connective tissue malignancy, and bladder cancer are among the high risks in these patients and need to be considered for them. Hence, the survival rate of the patients can be increased through prevention and early diagnosis.
Shamshirian Danial、Shadmehri Nima、Shamshirian Amir、Lotfi Parisa、Zamani-Kiasari Alieh、Rismantab Sahar、Heydari Keyvan、Alizadeh-Navaei Reza
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical SciencesScience Department, University of TehranDepartment of Medical Laboratory Sciences, Student Research Committee, School of Allied Medical Science, Mazandaran University of Medical Sciences||Gastrointestinal Cancer Research Center, Mazandaran University of Medical SciencesStudent Research Committee, School of Medicine, Mazandaran University of Medical SciencesDepartment of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical SciencesRamsar Campus, Mazandaran University of Medical SciencesStudent Research Committee, School of Medicine, Mazandaran University of Medical Sciences||Gastrointestinal Cancer Research Center, Mazandaran University of Medical SciencesGastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences
肿瘤学医学研究方法妇产科学
Ovarian cancerSecondary malignancySecondary cancerSIRMeta-analysis
Shamshirian Danial,Shadmehri Nima,Shamshirian Amir,Lotfi Parisa,Zamani-Kiasari Alieh,Rismantab Sahar,Heydari Keyvan,Alizadeh-Navaei Reza.The Risk of Secondary Malignancies in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2020.04.07.20057190.点此复制
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