脑出血后血脑屏障损伤机制的研究进展

his paper summarized the main research progress which was relevant to the potential mechanisms of secondaryblood-brain barrier (BBB) dysfunction in adults' intracerebral hemorrhage (ICH). ICH correlated with many causes, illustratingwith examples, cerebral vascular malformations, coagulopathies, high blood pressure and Alzheimer's disease. Remarkableachievement of the cell and molecular signal level has been obtained on the etiologies of BBB dysfunction after ICH.Hemoglobin, thrombin, iron of blood compositions and the inflammatory reaction to them have a big impact on BBBdysfunction after ICH. Knowing the mechanisms underlying the secondary BBB dysfunction after ICH is significant forstudying the pathogenesis of cerebral hemorrhagic stroke.