来氟米特治疗类风湿关节炎的Meta分析

Objective: Evaluate the therapeutic effect of Leflunomide in the treatment of rheumatoid arthritis. Methods: We searched WanFang, VIP, CNKI and Data CBM for the treatment of rheumatoid arthritis (RA). Meta analysis was carried out using RevMan 5.3 software with 2 reviewers independently selecting the test, extracting the data and assessing the quality of the method. Results: 6 studies were included. The results of Meta analysis showed that LEF was superior in terms of MTX or other drugs of control group, and the difference was statistically significant: C reactive protein [MD = - 4.29, 95%CI (- 0.32, 8.27), P=0.03], The number of swollen joints [MD = 1.84, 95%CI (- 2.99, 0.69), P=0.002]. No statistical significance in ESR, time of morning stiffness and rheumatoid factor differences. Conclusion: the results of the Meta analysis showed that the Leflunomide was superior to the control group, but the difference was not statistically significant in many therapeutic effects,. Because the sample size is small and the quality is low, the conclusion still needs to be confirmed by the high quality and large sample randomized blind controlled trial.