Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
Abstract Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state fMRI studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity across the whole-brain functional network can provide a better characterization of age-related changes. Here we employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent (BOLD) signals to analyze resting-state fMRI data from 620 subjects divided into two groups (‘middle-age group’ (n=310); age range, 50-65 years vs. ‘older group’ (n=310); age range, 66-91 years). Applying the Intrinsic-Ignition Framework to assess the effect of spontaneous local activation events on local-global integration, we found that the older group showed higher intrinsic ignition across the whole-brain functional network, but lower metastability. Using Leading Eigenvector Dynamics Analysis, we found that the older group showed reduced ability to access a metastable substate that closely overlaps with the so-called rich club. These findings suggest that functional whole-brain dynamics are altered in aging, probably due to a deficiency in a metastable substate that is key for efficient global communication in the brain.
Essig Marco、Gallart Lu¨as、Escrichs Anira、Brugada Ramon、Serena Joaquin、Rami¨?-Torrent¨¤ Llu¨as、Mayneris-Perxachs Jordi、Pedraza Salvador、Biarnes Carles、Puig Josep、Garre-Olmo Josep、Fern¨￠ndez-Real Jos¨| Manuel、Coll-De-Tuero Gabriel、Ramos Rafel、Figley Chase R.、Deco Gustavo、Pamplona Reinald、Vilanova Joan C.、Barretina Jordi
Department of Radiology, University of ManitobaBiobanc, Girona Biomedical Research Institute (IDIBGI)Computational Neuroscience Group, Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu FabraGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of Girona||Cardiovascular Genetics Center, IDIBGI, CIBER-CVGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of Girona||Department of Neurology, Hospital Universitari de Girona Dr Josep TruetaGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of Girona||Department of Neurology, Hospital Universitari de Girona Dr Josep TruetaGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Diabetes, Endocrinology and Nutrition, IDIBGI, Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatolog¨aa de la Obesidad y Nutrici¨?n (CIBERobn)Department of Radiology (IDI), Hospital Universitari de Girona Dr Josep Trueta||Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of GironaDepartment of Radiology (IDI), Hospital Universitari de Girona Dr Josep Trueta||Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep TruetaDepartment of Radiology (IDI), Hospital Universitari de Girona Dr Josep Trueta||Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of GironaGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of Girona||Institut d?ˉAssist¨¨ncia Sanit¨¤riaGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of Girona||Department of Diabetes, Endocrinology and Nutrition, IDIBGI, Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatolog¨aa de la Obesidad y Nutrici¨?n (CIBERobn)Department of Medical Sciences, School of Medicine, University of Girona||Vascular Health Research Group of Girona (ISV-Girona), Institut Universitari d?ˉInvestigaci¨? en Atenci¨? Prim¨¤ria Jordi Gol (IDIAP Jordi Gol)||CIBER of Epidemiology and Public Health (CIBERESP)Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of Girona||Vascular Health Research Group of Girona (ISV-Girona), Institut Universitari d?ˉInvestigaci¨? en Atenci¨? Prim¨¤ria Jordi Gol (IDIAP Jordi Gol)||Primary Care Services, Catalan Institute of Health (ICS)Department of Radiology, University of ManitobaComputational Neuroscience Group, Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra||Institucio Catalana de la Recerca i Estudis Avancats (ICREA)||Department of Neuropsychology, Max Planck Institute for human Cognitive and Brain Sciences||Turner Institute for Brain and Mental Health, Monash UniversityDepartment of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleidaDepartment of Radiology (IDI), Hospital Universitari de Girona Dr Josep Trueta||Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta||Department of Medical Sciences, School of Medicine, University of GironaGirona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
agingmetastabilityrich-clubresting-state fMRIwhole-brain dynamics
Essig Marco,Gallart Lu¨as,Escrichs Anira,Brugada Ramon,Serena Joaquin,Rami¨?-Torrent¨¤ Llu¨as,Mayneris-Perxachs Jordi,Pedraza Salvador,Biarnes Carles,Puig Josep,Garre-Olmo Josep,Fern¨￠ndez-Real Jos¨| Manuel,Coll-De-Tuero Gabriel,Ramos Rafel,Figley Chase R.,Deco Gustavo,Pamplona Reinald,Vilanova Joan C.,Barretina Jordi.Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club[EB/OL].(2025-03-28)[2025-07-16].https://www.biorxiv.org/content/10.1101/2020.06.29.164343.点此复制
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