肾素基因启动子区域甲基化水平与精神分裂症患者认知损害的关联

o explore the potential role of renin gene promoter methylation on pathogenesis of schizophrenia, we tested the methylation level of CpG in renin gene promoter from peripheral blood of schizophrenia patients and healthy controls. The rapid visual information processing (RVP) and delayed matching to samples (DMS) tests of Cambridge Neuropsychological Test Automatic Battery were performed to assess the Association between renin gene methylation and schizophrenia cognitionattention and visual memory of subjects form Association between renin gene methylation and cognitive impairments in schizophreniatwo groups. The association between CpG methylation levels of renin gene promoter and the two cognition domains were analyzed by partial correlation. The methylation levels of all CpG in renin gene promoter showed no significant difference between two groups. After setting gender, age and disease status as covariate, the methylation level of CpG cite chr1:204166158 (hg38) as significantly correlated with RVP total correct rejection (r=-0.68, p=2.42×10-7), RVP A\' (r=-0.61, p=6.94×10-6), DMS total correct(r=-0.55,p=1.02×10-4), DMS total correct all delays (r=-0.54, p=.52×10-4). The renin gene may play an important role in the pathology of schizophrenia through promoter methylation.