Prediction of coronary disease incidence in the general population by circulating RNY(YRNA)-derived small RNA
Prediction of coronary disease incidence in the general population by circulating RNY(YRNA)-derived small RNA
ABSTRACT During the development of atherosclerotic lesion, s-RNYs (small RNAs of about 24/34 nucleotides) are derived by the processing of long Ro-associated non-coding RNAs (RNYs) in macrophages. The levels of serum s-RNYs have been found significantly upregulated in patients with coronary heart disease (CHD) compared to age-matched healthy individuals. The present study aimed to examine the predictive value of serum s-RNYs for CHD events in the general population. Within the frame of nested-case-control study, the GENES study, we measured the absolute expression of a RNY-derived small RNA, the s-RNY1-5p, in the serum of healthy individuals who encountered a CHD event within 12 years of follow-up (n = 31) (Cases) and compared them to individuals who remained event-free (Controls) (n = 30). The expression of s-RNY1-5p in serum was significantly upregulated in Cases compared to Controls (p = 0.027). The proportion of CHD event-free was significantly higher among individuals with serum s-RNY1-5p below the median value (631 molecule / mL). In a multivariate model adjusted for age, smoking and treatment for hypertension, diabetes and dyslipidemia, the risk of CHD events increased more than 4-fold in individuals with serum s-RNY1-5p above the median value (HR, 4.36; 95%CI, 1.22-15.60). Significant association with CHD events was also observed when considering s-RNY1-5p as a continuous variable (p = 0.022). Serum s-RNY1-5p is an independent predictor of CHD in healthy individuals and could be considered as a biomarker in primary prevention of cardiovascular diseases. TRANSLATIONAL PERSPECTIVESHere, we reported that s-RNY1-5p was significantly upregulated in the serum of individuals who underwent CHD and was positively associated with CHD events. Those results argue in favor of s-RNY1-5p being a novel predictive molecular biomarker for cardiovascular events. In the future, measurement of s-RNY1-5p expression levels and other 5’ s-RNYs, such as s-RNY4-5p, could be used in clinical practice in addition to classical risk factors to identify those high-risk individuals who might benefit from prevention medicine.
Ruidavet Jean-Bernard、Trabucchi Michele、Serra Fabrizio、Claire Mauduit、Grandjean Valerie、Repetto Emanuela、Stathopoulou Maria G.、Ferri¨¨res Jean、Perret Bertrand、Costa Vera L.、Bongard Vanina、Benahmed Mohamed、Martinez Laurent O.
Department of Epidemiology, Health Economics and Public Health, UMR1027 INSERM, Toulouse University, Toulouse University Hospital (CHU)Inserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurInserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurInserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurInserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurInserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurInserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurDepartment of Epidemiology, Health Economics and Public Health, UMR1027 INSERM, Toulouse University, Toulouse University Hospital (CHU)||F¨|d¨|ration de Cardiologie, Toulouse University Hospital (CHU)Institut National de la Sant¨| et de la Recherche M¨|dicale (INSERM)||University of Toulouse, UMR1048, Paul Sabatier University||Service de Biochimie, P?le biologie, H?pital de PurpanInserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurDepartment of Epidemiology, Health Economics and Public Health, UMR1027 INSERM, Toulouse University, Toulouse University Hospital (CHU)||F¨|d¨|ration de Cardiologie, Toulouse University Hospital (CHU)Inserm U1065, C3M, Team Control of Gene Expression (10), Universit¨| C?te d?ˉAzurDepartment of Epidemiology, Health Economics and Public Health, UMR1027 INSERM, Toulouse University, Toulouse University Hospital (CHU)||Institut National de la Sant¨| et de la Recherche M¨|dicale (INSERM)
医药卫生理论预防医学基础医学
Y-RNAatherosclerosiscoronary heart diseasemolecular biomarkerprimary preventionprediction
Ruidavet Jean-Bernard,Trabucchi Michele,Serra Fabrizio,Claire Mauduit,Grandjean Valerie,Repetto Emanuela,Stathopoulou Maria G.,Ferri¨¨res Jean,Perret Bertrand,Costa Vera L.,Bongard Vanina,Benahmed Mohamed,Martinez Laurent O..Prediction of coronary disease incidence in the general population by circulating RNY(YRNA)-derived small RNA[EB/OL].(2025-03-28)[2025-07-02].https://www.medrxiv.org/content/10.1101/2020.03.24.20042812.点此复制
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