Systematic Review and Meta-Analysis Identifies Significant Relationships Between Anxiety Disorders and Daytime Lower Urinary Tract Symptoms
Systematic Review and Meta-Analysis Identifies Significant Relationships Between Anxiety Disorders and Daytime Lower Urinary Tract Symptoms
Abstract BackgroundClinically, lower urinary tract symptoms (LUTS), such as voiding symptoms, overactive bladder, and interstitial cystitis, are associated with anxiety disorders. However, the existing evidence for the overlap of these conditions has not been systematically evaluated. The aim of this study was to examine this relationship. MethodsWe conducted a systematic review and meta-analysis to examine the relationship between LUTS and anxiety. We searched for articles published from January 1990 to July 2019 in PubMed, CENTRAL, PsycINFO, and Google Scholar. Outcomes were anxiety-related disorders and symptoms “clinical anxiety”) and subtypes of LUTS. We performed random-effect meta-analyses, and inspected funnel plots and applied the Egger’s test to evaluate publication bias. We followed PRISMA guidelines and recorded our protocol on PROSPERO (ID=CRD42019118607). ResultsWe identified 814 articles, of which 94 fulfilled inclusion criteria and 23 had sufficient data for meta-analysis. The odds ratio for clinical anxiety among individuals with LUTS was 2.87 (95% CI: 2.38,3.46, P < 0.001). Very few studies looked at LUTS among individuals ascertained for clinical anxiety, but there appear to be significantly elevated odds ratio here as well. A large I2 value suggests high heterogeneity between studies. ConclusionsThe results demonstrate a clinically significant association between clinical anxiety and LUTS. There were limited data on youth, which should motivate further study in this area. Understanding the co-occurrence of these conditions will lead to better prevention and interventions to ameliorate the progression of the symptoms and to improve quality of life.
Buxbaum Joseph D.、Grice Dorothy E.、Janecka Magdalena、Hultman Christina M.、Reichenberg Abraham、Akre Olof、Mahjani Behrang、Mahjani Christina Gustavsson、Koskela Lotta Renstr?m、Batuure Anita
Department of Psychiatry, Icahn School of Medicine at Mount Sinai||Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai||Department of Medical Epidemiology and Biostatistics, Karolinska Institutet||Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai||Department of Neuroscience, Icahn School of Medicine at Mount Sinai||The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai||The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai||Division of Tics, Obsessive-Compulsive Disorder (OCD) and Related Disorders, Icahn School of Medicine at Mount Sinai||Friedman Brain Institute, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai||Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount SinaiDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai||Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount SinaiDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai||Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai||Department of Medical Epidemiology and Biostatistics, Karolinska Institutet||Division of Tics, Obsessive-Compulsive Disorder (OCD) and Related Disorders, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai||Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai||Department of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai||Division of Tics, Obsessive-Compulsive Disorder (OCD) and Related Disorders, Icahn School of Medicine at Mount Sinai
医学研究方法神经病学、精神病学内科学
anxiety disordersobsessive-compulsive disorderlower urinary tract symptomsoveractive bladderinterstitial cystitis
Buxbaum Joseph D.,Grice Dorothy E.,Janecka Magdalena,Hultman Christina M.,Reichenberg Abraham,Akre Olof,Mahjani Behrang,Mahjani Christina Gustavsson,Koskela Lotta Renstr?m,Batuure Anita.Systematic Review and Meta-Analysis Identifies Significant Relationships Between Anxiety Disorders and Daytime Lower Urinary Tract Symptoms[EB/OL].(2025-03-28)[2025-06-10].https://www.medrxiv.org/content/10.1101/2020.08.27.20183467.点此复制
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