热熔挤出制备PCL基药物缓释体系及其释药行为的研究

In this paper poly(ε-caprolactone) (PCL) based drug release systems were prepared through hot-melt extrusion (HME). Two poorly water-soluble drugs, ibuprofen (BF) and diclofenac sodium (DS), were used as the model drugs. DSC, XRD and SEM results revealed that the dispersion of the drugs were different due to their different melting temperatures, in-vitro release tests exhibited the different release behavior between BF and DS from the PCL matrix. Based on the experimental results, it was speculated that BF was amorphous or well dispersed in the PCL matrix after HME, while DS was dispersed as crystal particles (particle diameter was around 0.5 μm). The drug release behavior exhibited that the release of BF was much faster than that of DS, which was mainly due to the different dispersion and morphology of the two drugs.