离子液体负载法合成七聚核糖醇磷酸酯

eichoic acid is a major component of Gram-positive bacterial cell wall, which is an important bacterial antigen and plays vital roles in immune-modulating the interaction with host cells. Here we report a fast and efficient method to synthesize heptamer ribitol phosphate by using ionic liqued as soluble supports. Through adjusting the solubility of ionic liquid support in organic solvents, pure product was was obtained easily by simple washing off the excess reagents and by products. Time-consuming and costly chromatography purification processes are no longer needed.